Karl Fischer & Potentiometric Titration Application Library
Standardization of perchloric acid in acetic acid with potassium hydrogen phthalate | Autotitrator
Measurement method with perchloric acid – acetic acid standard solution is defined as a quantitative determination method for each drug and medicine in Japanese Pharmacopoeia. Standardization of perchloric acid – acetic acid standard solution with potassium hydrogen phthalate is also described there. This report introduces the standardization procedure that potassium hydrogen phthalate is dissolved in acetic acid, then it is titrated with perchloric acid – acetic acid standard solution. The factor of perchloric acid – acetic acid standard solution is determined with potentiometric titration. 1 mol potassium hydrogen phthalate reacts with 1 mol perchloric acid quantitatively on this titration (formula 1).
Purity determination for papaverine hydrochloride by perchloric aid titration | Autotitrator
Determination for papaverine hydrochloride is defined in Japanese Pharmacopoeia. Papaverine hydrochloride is used for improvement of vasodilatation and symptoms on gastritis, disease of biliary tract (gallbladder) system, acute arterial embolus, acute pulmonary embolism, peripheral circulatory failure, and inadequate coronary circulation.
The purity determination of papaverine hydrochloride using potentiometric titration with perchloric acid titrant is introduced in this report. Sample is dissolved by heating with acetic anhydride / glacial acetic acid mixture and cooled to room temperature. After that, the titration is performed, 1 mol papaverine hydrochloride reacts with 1 mol perchloric acid quantitatively.
The purity determination of papaverine hydrochloride using potentiometric titration with perchloric acid titrant is introduced in this report. Sample is dissolved by heating with acetic anhydride / glacial acetic acid mixture and cooled to room temperature. After that, the titration is performed, 1 mol papaverine hydrochloride reacts with 1 mol perchloric acid quantitatively.
Sodium chloride in peritoneal dialysis solution | Autotitrator
This report introduces an example of measurement for sodium chloride in peritoneal dialysis solution with precipitation titration. The sample is acidified by nitric acid and the concentration of sodium chloride is determined by precipitation titration with silver nitrate titrant using the silver / reference electrode.
NaCl ＋ AgNO₃ → AgCl ＋ NaNO₃
NaCl ＋ AgNO₃ → AgCl ＋ NaNO₃
Available Iodine Determination in Povidone-Iodine by Titration
Determine available iodine in povidone-iodine formulations using titration. Ensure accurate quality control of pharmaceutical antiseptics.
Determination of sodium acetate with perchloric acid titration | Autotitrator
Sodium acetate is widely used in chemical and medical industry (E.g. Buffer, Antifreezing agent, Alkalizing supplements, Dye chemical, Hydragogue). Determination method of sodium acetate is described on Japanese Pharmacopoeia and Japanese Industrial Standard (JIS K8371). Both methods employ perchloric acid titration method, dissolve the sample in glacial acetic acid and titrate with perchloric acid – acetic acid standard solution. Endpoint is detected by potentiometric titration with glass / reference electrodes.
CH₃COONa ＋ HClO₄ → CH₃COOH ＋ NaClO₄
CH₃COONa ＋ HClO₄ → CH₃COOH ＋ NaClO₄
Iodine Value Determination of Cooking Oils Using Automated Titration
Determine iodine value in cooking oils to measure unsaturation and quality. Improve oil characterization and quality control with automated titration.
Acid value of cooking oil | Autotitrator
Acid value of oils and fats is defined as “amount (mg) of potassium hydroxide required to neutralize fatty acid in 1 g of sample” (Formula (1)).
R-COOH + KOH → R-COOK + H₂O ・・・(1)
It is used for evaluation of free fatty acid content as quality index of oils and fats. This method is described in a variety of official standards such as “Japan Agricultural Standards” and Pharmacopoeias. Example of titration for acid value in cooking oil is introduced here.
Reference
1) Japanese Pharmacopoeia Seventeenth Edition
R-COOH + KOH → R-COOK + H₂O ・・・(1)
It is used for evaluation of free fatty acid content as quality index of oils and fats. This method is described in a variety of official standards such as “Japan Agricultural Standards” and Pharmacopoeias. Example of titration for acid value in cooking oil is introduced here.
Reference
1) Japanese Pharmacopoeia Seventeenth Edition
Simultaneous Determination of Citric Acid and Vitamin C in Soft Drinks Using Automated Titration
Simultaneous citric acid and vitamin C analysis in soft drinks using automated titration. Improve beverage quality, consistency, and nutritional control.
Salt Content in Soy Sauce | Autotitrator
The determination method of salt content in soy sauce is described as “Measurement of Salt Content” in JAS (Japanese Agriculture Standard). Potentiometric titration and Mohr method is defined in JAS as determination method of salt content, potentiometric titration is more common method because of its ease and high precision. The sample is acidified by nitric acid and the concentration of salt is determined byprecipitation titration with silver nitrate titrant using the silver electrode.
NaCl ＋ AgNO₃ → AgCl ＋ NaNO₃
Simultaneous Salt and Acidity Determination in Salad Dressing Using Automated Titration
Simultaneous salt and acidity measurement in salad dressing using automated titration. Improve QC efficiency and ensure consistent product quality.
