ADME HPLC Columns
Optimized Phases for Drug Metabolism and Bioanalytical Analysis
Conventional C18 columns often provide insufficient retention for highly polar drug metabolites and conjugated compounds. ADME-optimized stationary phases are designed to increase retention, improve peak shape, and enhance selectivity for polar analytes encountered in drug metabolism and pharmacokinetic studies.
JM Science offers three specialized ADME platforms to address different analytical priorities.
Why ADME-Specific Columns?
ADME (Absorption, Distribution, Metabolism, and Excretion) workflows frequently involve:
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Glucuronides and sulfate conjugates
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Hydroxylated metabolites
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Highly polar drug intermediates
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Early-eluting compounds in LC-MS methods
Standard reversed-phase C18 columns may result in:
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Poor retention
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Co-elution with void volume
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Insufficient resolution of metabolites
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Secondary interactions in LC-MS systems
ADME phases are engineered to address these challenges.
ADME Platform Comparison
| Series | Technology | Primary Advantage | Best Application |
|---|---|---|---|
| ADME-HR | Fully porous | High retention and robust general-purpose ADME selectivity | Routine ADME and metabolite profiling |
| CORE ADME | Core-shell 2.7 µm | High efficiency and faster analysis at moderate backpressure | High-speed ADME and LC-MS workflows |
| INERT ADME | Low-metal interaction design | Reduced adsorption of metal-sensitive analytes | LC-MS bioanalysis of chelating or adsorption-prone compounds |
ADME-HR
General-purpose ADME phase providing strong retention for polar metabolites while maintaining classical reversed-phase behavior. Ideal for laboratories seeking a robust and broadly applicable ADME column.
CORE ADME
Core-shell technology provides high theoretical plate counts while maintaining moderate system pressure. Particularly useful when:
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Increasing throughput
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Improving resolution
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Shortening analysis time
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Operating on conventional HPLC systems
INERT ADME
Designed for analytes susceptible to metal adsorption. Suitable for LC-MS bioanalysis and compounds where peak tailing or adsorption has been observed on conventional hardware.
Need Assistance Selecting the Proper ADME Phase?
JM Science provides technical support for method development, column selection, and workflow optimization. Contact our chromatography specialists for guidance to sales@jmscience.com or Tel: 716-774-8706