Capcell CORE ADME HPLC Columns

High-Speed LC-MS Performance with Core-Shell Technology

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Overview

Capcell CORE ADME HPLC Columns combine advanced core-shell particle technology with the unique adamantylethyl stationary phase, delivering fast, high-efficiency separations ideal for modern LC and LC-MS workflows.

Designed for laboratories requiring high throughput without sacrificing resolution, CORE ADME columns provide excellent performance at lower backpressure compared to fully porous sub-2 μm columns.

Why CORE ADME?

• Core-shell (2.7 μm) particles for high efficiency and speed
• Lower backpressure vs sub-2 μm columns → compatible with standard HPLC systems
• Adamantylethyl phase for unique selectivity vs traditional C18
• Excellent retention of polar compounds under aqueous conditions
• Ideal for LC-MS/MS applications requiring sharp peaks and sensitivity

Core-Shell Technology Advantage

CORE-shell particles consist of:

• A solid, non-porous core
• A thin porous outer layer

This structure reduces analyte diffusion paths, resulting in:

• Faster mass transfer
• Sharper peaks
• Improved resolution
• Reduced analysis time

Analytical Capability Summary

Performance Benefits

• Faster run times → Increased sample throughput
• Reduced solvent consumption → Lower operating costs
• Improved peak shape → Better quantitation
• Enhanced sensitivity → Ideal for trace analysis
• Drop-in replacement for many existing HPLC methods

Ideal Applications

• Pharmaceutical ADME studies
• LC-MS/MS bioanalysis
• Food and beverage testing
• Environmental analysis
• Chemical and fine chemical analysis

Eliminate Ion-Pair Reagents in LC-MS Analysis

Ion-pair reagents such as TFA, HFBA, and alkyl sulfonates are commonly used to retain polar and ionic compounds on conventional C18 columns. However, these additives introduce significant challenges in LC-MS workflows.

Common issues with ion-pairing methods include:

• Ion suppression leading to reduced MS sensitivity
• Contamination of the ion source and transfer lines
• Increased baseline noise and signal instability
• Long equilibration times and poor reproducibility

Capcell CORE ADME HPLC columns provide an effective alternative.

The unique adamantylethyl stationary phase delivers strong retention of polar compounds under highly aqueous conditions—without the need for ion-pair reagents.

Benefits of eliminating ion pairing:

• Improved MS signal intensity and sensitivity
• Cleaner ion source and reduced maintenance
• Faster method development and equilibration
• Greater method robustness and reproducibility

By enabling LC-MS analysis with simple, MS-compatible mobile phases (water, acetonitrile, and volatile buffers), CORE ADME columns streamline workflows while improving analytical performance.

Comparison: CORE ADME vs Fully Porous ADME-HR

When to Choose CORE ADME

Choose CORE ADME when you need:

• Faster analysis without UHPLC pressure limits
• High efficiency on conventional HPLC systems
• LC-MS compatibility with sharp peak profiles
• Improved productivity in high-throughput labs

When to Choose ADME-HR Instead

Choose ADME-HR when you need:

• Maximum resolution
• Greater flexibility in particle size
• Established method transfer from traditional columns

Available Configurations

• Typical dimensions:
  • 2.1 × 50 mm
  • 2.1 × 100 mm
  • 4.6 × 100 mm
• Particle size:
  • 2.7 μm (core-shell)

Call to Action

Upgrade your HPLC performance without upgrading your system.

Capcell CORE ADME columns deliver the speed of UHPLC with the practicality of standard HPLC systems.