The Capcell Pak ADME-HR is a reversed-phase system in which an innovative cage-shaped functional group called Adamantyl group is introduced.
The Adamantyl group features a completely different structure to the conventional octadecyl group as the functional group. The implementation rate is tightly controlled at an optimized density in order to maximize the performance of ADME group. This provides a balance between a hitherto unavailable hydrophobicity and surface polarity of the particles.
ADME brings you separation patterns unavailable with conventional C18 columns. The diamond-like strength of Adamanitine provide diamond-sharp peaks.
This column has moderate hydrophobicity with high surface polarity and exhibits high retention for high-polarity compounds. These columns also have specific selectivity and are effective to change the selectivity and separation pattern of commonly used columns such as the C18 column.
High performance liquid chromatography (HPLC) is one of the most popular techniques of analytical chemistry. The performance of the analytical system largely depends on that of columns.
Non-conventional separation patterns derived by the high surface polarity
The Capcell Pak ADME-HR maintains a balance between hydrophobicity with surface polarity which is completely different to conventional particles and provides previously unavailable separation patterns.
In particular, in comparison to conventional C18 columns, increased retention to highly polar compounds have been demonstrated.
Highly stable under 100% Aqueous Mobile Phases
As shown on the right, the efficiency is very stable even after 600 injections under acidic mobile phase.
Analysis of Nucleic-Acid Bases and Nucleosides via Gradient Elution
As shown below, the unique selectivity provided from CAPCELL PAK ADME-HR shows complete separation for all analytes, but with stronger retention of polar analytes.
Retention Behavior of Biogenic Amines under 100 % Water Based Mobile Phase
As shown below, CAPCELL PAK ADME-HR offers stronger retention of polar analytes, resulting in delivering complete separation for all analytes.