Description
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CAPCELL PAK INERT ADME-HR HPLC Columns
Preferred for LC-MS and Metal-Sensitive Applications
CAPCELL PAK INERT ADME-HR columns combine the adamantyl stationary phase with inert internal hardware to minimize metal interaction and secondary adsorption.
For LC-MS workflows and trace-level analysis, even minor interaction with stainless steel surfaces can affect peak shape and recovery. The INERT configuration reduces this risk through PEEK-lined flow paths and inert frit design.
Because the cost difference relative to standard ADME-HR is modest, INERT is frequently selected as the preferred configuration for LC-MS method development and validation.
CAPCELL PAK INERT ADME-HR columns combine the unique adamantyl stationary phase with specially engineered inert hardware to minimize metal interactions and secondary adsorption effects.
While standard stainless steel column hardware is suitable for most applications, certain analytes — particularly nucleotides, phosphate-containing compounds, peptides, and metal-chelating species — can exhibit peak tailing or reduced recovery due to interaction with metal surfaces.
The INERT configuration addresses this challenge through:
• PEEK-lined internal surfaces
• Inert frit design
• Reduced metal exposure throughout the flow path
The result is:
• Improved peak symmetry
• Reduced adsorption
• Enhanced sensitivity
• Improved reproducibility in LC/MS workflows
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Key Characteristics
Stationary Phase: Adamantyl (ADME)
Pore Size: 100 Å
Particle Sizes: 2 µm, 3 µm
pH Range: 2–9
Pressure Resistance: Up to 80 MPa (2 µm)Benefits:
• Reduced metal interaction
• Excellent peak shape for metal-sensitive compounds
• No carry-over effects
• Stable under highly aqueous mobile phasesSpecifications
When to Choose INERT ADME-HR
Select the INERT configuration when:
• Peak tailing is observed on standard stainless steel columns
• Analytes contain phosphate groups
• Chelating agents or metal-binding compounds are present
• LC-MS sensitivity is compromised by adsorption
For most general polar analyte retention applications, standard ADME-HR is appropriate.