Karl Fischer & Potentiometric Titration Application Library
Quantitative determination of sodium citrate | Autotitrator
Sodium citrate is used as anticaking agent for blood in pharmaceutical field. Quantitative determination method for sodium citrate is stipulated in Japanese Pharmacopoeia.
This report introduces an example of potentiometric titration for sodium citrate that well-dried sample is dissolved in acetic acid, then it is titrated with perchloric acid – acetic acid standard solution.
C₆H₅Na₃O₇ ＋ 3HClO₄ → C₆H₈O₇ ＋ 3NaClO₄
This report introduces an example of potentiometric titration for sodium citrate that well-dried sample is dissolved in acetic acid, then it is titrated with perchloric acid – acetic acid standard solution.
C₆H₅Na₃O₇ ＋ 3HClO₄ → C₆H₈O₇ ＋ 3NaClO₄
Standardization of perchloric acid in acetic acid with potassium hydrogen phthalate | Autotitrator
Measurement method with perchloric acid – acetic acid standard solution is defined as a quantitative determination method for each drug and medicine in Japanese Pharmacopoeia. Standardization of perchloric acid – acetic acid standard solution with potassium hydrogen phthalate is also described there. This report introduces the standardization procedure that potassium hydrogen phthalate is dissolved in acetic acid, then it is titrated with perchloric acid – acetic acid standard solution. The factor of perchloric acid – acetic acid standard solution is determined with potentiometric titration. 1 mol potassium hydrogen phthalate reacts with 1 mol perchloric acid quantitatively on this titration (formula 1).
Purity determination for papaverine hydrochloride by perchloric aid titration | Autotitrator
Determination for papaverine hydrochloride is defined in Japanese Pharmacopoeia. Papaverine hydrochloride is used for improvement of vasodilatation and symptoms on gastritis, disease of biliary tract (gallbladder) system, acute arterial embolus, acute pulmonary embolism, peripheral circulatory failure, and inadequate coronary circulation.
The purity determination of papaverine hydrochloride using potentiometric titration with perchloric acid titrant is introduced in this report. Sample is dissolved by heating with acetic anhydride / glacial acetic acid mixture and cooled to room temperature. After that, the titration is performed, 1 mol papaverine hydrochloride reacts with 1 mol perchloric acid quantitatively.
The purity determination of papaverine hydrochloride using potentiometric titration with perchloric acid titrant is introduced in this report. Sample is dissolved by heating with acetic anhydride / glacial acetic acid mixture and cooled to room temperature. After that, the titration is performed, 1 mol papaverine hydrochloride reacts with 1 mol perchloric acid quantitatively.
Sodium chloride in peritoneal dialysis solution | Autotitrator
This report introduces an example of measurement for sodium chloride in peritoneal dialysis solution with precipitation titration. The sample is acidified by nitric acid and the concentration of sodium chloride is determined by precipitation titration with silver nitrate titrant using the silver / reference electrode.
NaCl ＋ AgNO₃ → AgCl ＋ NaNO₃
NaCl ＋ AgNO₃ → AgCl ＋ NaNO₃
Available iodine in mouthwash (Povidone-iodine) | Autotitrator
Determination method of available iodine in mouthwash containing povidone-iodine which is described in Japanese Pharmacopoeia is introduced here.
Dispense the sample and dilute it with DI water. Redox titration with sodium thiosulfate is performed based on the following formula (1).
I₂ ＋ 2Na₂S₂O₃ → 2NaI ＋ Na₂S₄O₆・・・(1)
Dispense the sample and dilute it with DI water. Redox titration with sodium thiosulfate is performed based on the following formula (1).
I₂ ＋ 2Na₂S₂O₃ → 2NaI ＋ Na₂S₄O₆・・・(1)
Determination of sodium acetate with perchloric acid titration | Autotitrator
Sodium acetate is widely used in chemical and medical industry (E.g. Buffer, Antifreezing agent, Alkalizing supplements, Dye chemical, Hydragogue). Determination method of sodium acetate is described on Japanese Pharmacopoeia and Japanese Industrial Standard (JIS K8371). Both methods employ perchloric acid titration method, dissolve the sample in glacial acetic acid and titrate with perchloric acid – acetic acid standard solution. Endpoint is detected by potentiometric titration with glass / reference electrodes.
CH₃COONa ＋ HClO₄ → CH₃COOH ＋ NaClO₄
CH₃COONa ＋ HClO₄ → CH₃COOH ＋ NaClO₄
