Sodium Citrate Determination in Pharmaceutical Formulations
Why Measure Sodium Citrate?
Sodium citrate is widely used in pharmaceutical products as an anticoagulant, buffering agent, pH modifier, and stabilizer. It is commonly found in injectable solutions, blood collection systems, oral formulations, and effervescent products. Accurate assay of sodium citrate is essential for pharmaceutical quality control and pharmacopoeial compliance.
This application demonstrates a non-aqueous potentiometric titration based on the Japanese Pharmacopoeia using perchloric acid in acetic acid. Automated endpoint detection eliminates subjective visual indicators while improving analytical precision and repeatability.
Analytical Method
Technique
Potentiometric acid-base titration
Advantages
- Automatic endpoint detection
- Excellent repeatability
- Suitable for routine QC laboratories
- Eliminates subjective color indicator interpretation
Recommended Hiranuma Configuration
- COM-A19
- COM-28S
- Appropriate pH electrode
- Automatic burette
- Optional C-1724 autosampler
