CAPCELL PAK ADME-HR HPLC Columns
Enhanced Retention of Polar Compounds in Reversed-Phase HPLC
CAPCELL PAK ADME-HR HPLC columns utilize a unique adamantyl stationary phase designed to provide enhanced retention and selectivity for polar compounds under reversed-phase conditions.
Unlike conventional C18 columns, ADME-HR delivers:
- Increased retention of highly polar analytes
- Alternative selectivity for challenging separations
- Stable performance under highly aqueous mobile phases
👉 Ideal for applications where traditional C18 columns fail to retain polar compounds effectively.
🔬 Why ADME-HR is Different from C18
The ADME-HR stationary phase uses a cage-structured adamantyl functional group, providing a unique balance of:
- Hydrophobic interaction
- Surface polarity
This results in:
- Retention behavior not achievable with standard C18 columns
- Improved separation of polar metabolites and compounds
- Greater flexibility in reversed-phase method development
⚖️ ADME-HR vs C18 Columns
- C18: Strong hydrophobic retention, weak for polar compounds
- ADME-HR: Balanced retention with enhanced polarity interaction
👉 ADME-HR is the solution when:
- Polar analytes elute too early
- Retention is insufficient
- Selectivity needs improvement
🧪 Applications
Pharmaceutical Analysis
- Polar drug compounds
- Metabolites
- Nucleic acid-related compounds
Biochemical Analysis
- Nucleosides and nucleotides
- Amines and polar biomolecules
Food and Environmental
- Polar contaminants
- Additives and small molecules
🔬 Key Features
- Adamantyl stationary phase (ADME chemistry)
- Strong retention of polar analytes
- Stable under 100% aqueous mobile phase
- Unique selectivity vs conventional C18
- Excellent peak shape and reproducibility
⚠️ When to Choose ADME-HR
Use this column when:
- Polar compounds are poorly retained on C18
- Separation selectivity needs improvement
- Aqueous mobile phases are required
- You want to maintain reversed-phase conditions
🔧 Available Configurations
- Particle sizes: 2 µm, 3 µm, 5 µm
- Column IDs: 2.1 mm, 4.6 mm
- Lengths: 50–250 mm
📞 Request Information
👉 Request a quote
👉 Request application support
👉 Speak with an HPLC specialist
Contact Info: sales@jmscience.com; Tel: 716-774-8706
