Coulometric Karl Fischer Titrators

H1: Coulometric Karl Fischer Titrators

Accurate determination of trace levels of water is critical for many industries — from pharmaceuticals and chemicals to food and energy. JM Science offers a complete line of Coulometric Karl Fischer (KF) Titrators designed to deliver high precision, fast results, and ease of operation for laboratories that demand accuracy and reliability.

Coulometric vs Volumetric KF Titrators

Choosing the right Karl Fischer titrator is critical for accurate moisture analysis. Coulometric KF titrators are ideal for trace moisture detection, while Volumetric KF titrators are optimized for moderate to high water content samples. The table below highlights the key differences, helping you select the best instrument for your laboratory needs.

Feature	Coulometric KF	Volumetric KF
Measurement Range	Trace levels: 10 µg – 10 mg H₂O	Higher moisture: 0.01 – 500 mg H₂O
Titrant	Electrochemically generated iodine (no pre-made titrant)	Pre-prepared titrant (manual or automated burette)
Best For	Very low moisture samples	Moderate to high moisture samples
Speed	Slower for large samples	Faster for larger samples
Sample Types	Liquids, solids, gases (trace moisture)	Liquids, solids, pastes (higher moisture)
Automation	Fully automated for small samples	Automated burette systems for moderate/high volume
Accuracy	±1 µg H₂O or better	±0.1 – 1 mg H₂O depending on model
Applications	Pharmaceuticals, oils, polymers, chemicals with trace water	Food & beverages, chemicals, pharmaceuticals, polymers with moderate/high moisture
Compliance	ASTM E203, ISO 760, JIS K0068	ASTM E203, ISO 760, JIS K0068
Maintenance	Low, minimal reagents	Low, replace titrant as needed

H2: Why Choose Coulometric Karl Fischer Titration?

Coulometric KF titration is the preferred method for measuring low levels of water (10 µg to 10 mg) with exceptional accuracy. Unlike volumetric titration, the coulometric method generates iodine electrochemically, eliminating the need for titrant preparation and minimizing reagent waste.

At JM Science, our coulometric titrators combine sophisticated measurement technology with user-friendly operation to ensure consistent, reproducible results. Key advantages include:

High sensitivity for trace moisture detection

Automated operation with built-in endpoint detection

Fast titration speed for improved throughput

Compact design ideal for laboratory benchtops

Low reagent consumption reduces costs and waste

H2: JM Science Coulometric KF Titrator Models

(Here you can list your specific model names and a short comparison chart — I can create a table layout if you’d like.)
Example:

Model	Measurement Range	Display	Key Feature
AQUACOUNTER AQ-300	1 µg – 10 mg	LCD	Compact, easy operation
AQUACOUNTER Moico-A19	0.1 µg – 30%	Touchscreen	Dual cell system, high throughput

Model

Measurement Range

Display

Key Feature

AQUACOUNTER AQ-300

1 µg – 10 mg

LCD

Compact, easy operation

AQUACOUNTER Moico-A19

0.1 µg – 30%

Touchscreen

Dual cell system, high throughput

H2: Key Features and Benefits

JM Science’s AQUACOUNTER® series of Coulometric Karl Fischer Titrators are engineered for laboratory professionals who need reliable, trace-level moisture analysis.
Each instrument delivers consistent precision and long-term stability with minimal maintenance.

Key Benefits:

Automatic Moisture Analysis: No need to prepare iodine solutions — fully automated titration.
Wide Measurement Range: Detects water content from trace micrograms up to several milligrams.
User-Friendly Interface: Simple touchscreen or keypad operation with data memory.
Compact Design: Fits easily on laboratory benches while maintaining a high-performance cell system.
Low Maintenance: Electrolysis cell and generator electrode designed for long life.
Compliance Ready: Meets ASTM, ISO, and JIS moisture analysis standards.

H2: Typical Applications

Coulometric KF titration is ideal for samples containing very low moisture levels. Common applications include:

Pharmaceuticals: APIs, excipients, and lyophilized products
Petrochemicals: Oils, lubricants, fuels
Food & Beverages: Fats, sugars, and lyophilized powders
Chemicals & Solvents: Alcohols, esters, ketones, and acids
Plastics & Polymers: Resins and pellets
Environmental Testing: Moisture in soil and air samples

H2: Support and Resources

Access our full library of KF titration manuals, guides, and videos to help your team achieve accurate results.

Frequently Asked Questions

1. What is the difference between Coulometric and Volumetric Karl Fischer titration?

Coulometric titration is designed for very low water content samples (10 µg–10 mg), generating iodine electrochemically inside the titration cell. Volumetric titration, on the other hand, uses a liquid titrant and is more suitable for samples with higher moisture content. JM Science offers both types to match laboratory needs.

2. How accurate are JM Science Coulometric KF Titrators?

JM Science’s AQUACOUNTER® Coulometric Karl Fischer Titrators provide accuracy within ±1 µg H₂O or better, depending on sample size and conditions. Each system features automatic endpoint detection and drift compensation for consistent, reproducible results.

3. What kind of samples can be analyzed using a Coulometric KF Titrator?

Coulometric titration is ideal for trace moisture analysis in oils, resins, pharmaceuticals, solvents, plastics, and specialty chemicals. Solid, liquid, and gaseous samples can be tested using appropriate sample introduction systems.

4. How often should the reagent be replaced?

The replacement frequency depends on sample load and ambient humidity. As a rule of thumb, replace the anolyte every 2–3 weeks for regular use, or sooner if background drift increases. JM Science supplies ready-to-use reagents compatible with all AQUACOUNTER® models.

5. Are JM Science instruments compliant with ASTM and ISO standards?

Yes. All JM Science Karl Fischer titrators conform to ASTM E203, ISO 760, and JIS K0068 standards for moisture determination, ensuring full traceability and regulatory compliance for laboratory and production environments.

Customer Success Story

“We rely on JM Science’s Coulometric Karl Fischer titrator daily for trace moisture analysis in active pharmaceutical ingredients. Its precision and reliability have streamlined our QC testing process.”
— Quality Control Manager, Pharmaceutical Laboratory, Boston, MA

Real-World Application Example

A mid-sized pharmaceutical lab needed to verify low-level moisture in hygroscopic powders during raw material inspection. Their previous system required manual endpoint adjustments and frequent recalibration.
By switching to the JM Science AQUACOUNTER® Coulometric KF Titrator, they achieved:

Reduced analysis time by 25%
Improved repeatability to within ±1 µg H₂O
Automatic drift correction, minimizing operator variability

The result: faster throughput, less reagent waste, and improved data consistency.

H2: Request a Quote or Demo

Interested in learning which AQUACOUNTER® model best fits your lab?
Our technical specialists can help you select the right coulometric KF titrator based on your sample type and throughput needs.

➡ Contact JM Science
or call (716) 774-8706 for immediate assistance. Email sales@jmscience.com