Capcell Pak INERT HPLC Columns
Low-Metal Adsorption Technology for Demanding LC/MS Applications
Metal interaction between analytes and stainless-steel hardware can result in peak distortion, adsorption, and poor reproducibility — particularly for phosphorylated, acidic, or metal-coordinating compounds.
CAPCELL PAK INERT columns are engineered to minimize metal interaction and surface adsorption while maintaining the durability and reproducibility of polymer-coated silica technology.
Why INERT Technology?
Standard stainless-steel column hardware can interact with:
• Phosphorylated peptides
• Organic acids
• Metal-chelating compounds
• Biologically active analytes
• LC/MS-sensitive components
INERT technology reduces secondary adsorption and improves peak symmetry for analytes prone to metal interaction.
Performance Advantages
• Low adsorption characteristics
• Improved peak shape for metal-sensitive analytes
• Enhanced reproducibility in LC/MS workflows
• Pressure resistance up to 50 MPa (3 µm)
• Polymer-coated silica stability
INERT columns are particularly effective for gradient LC/MS methods using acidic mobile phases.
INERT Product Lineup
The INERT series includes multiple phase options:
• INERT C18 MGIII
• INERT C18 ACR
• INERT C8 DD
• INERT ADME-HR
Available in 2 µm and 3 µm particle sizes with 2.0 mm I.D. formats.
Applications
INERT columns are widely used for:
• Phosphorylated peptide analysis
• Pharmaceutical impurity profiling
• Natural product analysis
• LC/MS method development
• Food safety testing
• Mycotoxin analysis
Low adsorption performance enables sharper peaks and improved sensitivity.
When to Choose INERT vs ADME vs CORE
Choose INERT when:
• Peak tailing suggests metal interaction
• Analytes contain phosphate or carboxyl groups
• LC/MS sensitivity is compromised
Choose ADME for enhanced polar retention and selectivity.
Choose CORE for high-speed, low-backpressure separations.
Explore INERT Configurations
View available dimensions and particle sizes below.
Request Application Support
If you are experiencing peak tailing, adsorption, or poor recovery, our team can help determine the best INERT column for your application.
👉 Request application support or a quotation
Contact Info: sales@jmscience.com; Tel: 716-774-8706