Ascorbic acid (vitamin C) and sodium ascorbate are widely used in pharmaceutical and nutraceutical formulations as active ingredients and antioxidants. Accurate determination of each component is essential for product quality, formulation verification, and regulatory compliance. This application demonstrates a sequential potentiometric titration that independently quantifies ascorbic acid and sodium ascorbate using automated neutralization and redox titration methods.
Technical Summary
Ascorbic acid and sodium ascorbate are sequentially determined using two automated potentiometric titrations. Ascorbic acid is first measured by neutralization with standardized sodium hydroxide, followed by redox titration with iodine to determine the total vitamin C content. The sodium ascorbate concentration is then calculated by difference, providing accurate and reproducible results for routine quality control.
